In the rapidly evolving landscape of drug discovery and development, biocatalysis and biotransformation have become increasingly important. Our company has established a dedicated Bio Transformation Platform. Built on the foundation of our Research Chemistry Platform and Chemistry Technology Platform, this platform is designed to deliver cutting edge enzymatic research services to support clients' discovery and process development efforts.
Overview of our Bio-Transformation Platform
In modern drug discovery and process development, biotransformation has emerged as a critical tool for achieving efficient, selective, and environmentally friendly chemical transformations. Our bio transformation platform is designed to provide end-to-end enzymatic research services that accelerate small-molecule development from discovery to scale-up. By leveraging a diverse enzyme library, advanced high-throughput screening, process optimization techniques, and enzyme engineering capabilities, the platform enables precise and scalable biocatalytic solutions. Whether it is identifying the optimal enzyme for a reaction, improving reaction efficiency, or developing a scalable process, our platform offers the expertise and resources necessary to meet complex project needs.
Our Services
Within the bio transformation platform, we offer a suite of services tailored to different stages and objectives:
High-Throughput Enzyme Screening
Rapidly screen large enzyme libraries against target substrates to identify hits that deliver desired transformations (e.g., reduction, hydrolysis, amination, oxidation, etc.). This helps clients quickly assess feasibility and select promising biocatalysts.
Process Optimization
Optimize reaction conditions (pH, temperature, co factors, substrate concentration, solvent, etc.) to maximize yield, selectivity (e.g., enantioselectivity), and enzyme performance. This includes optimizing for throughput, purity, and downstream work up strategy.
Enzyme Evolution / Engineering
In cases where naturally available enzymes are insufficient in activity, selectivity, or stability, we provide enzyme engineering / evolution services to tailor biocatalysts, improving properties such as substrate scope, turnover number, stability under process conditions, and stereoselectivity.
Customized Biotransformation Development
Beyond generic services, we offer project specific, client tailored development — combining our chemical knowledge and biotransformation expertise to solve challenging transformations (e.g., asymmetric reductions, selective hydrolysis, asymmetric amination, stereoselective double bond reductions, etc.).
In this way, our platform serves both early discovery needs (rapid feasibility, screening) and later stage process development.
Why Choose Us?
- Broad and Diverse Enzyme Toolbox: The availability of a large and diverse enzyme library — hydrolases, ketoreductases, transaminases, dehydrogenases, reductases, monooxygenases, etc. — enables us to tackle a wide variety of reaction types, from hydrolysis and reductions to oxidations and aminations.
- Strong Technology Support: In addition to a broad enzyme repertoire, our platform integrates detection technologies, chiral resolution methods, and process‑considerations (e.g., reaction conditions, product isolation) to ensure robust deliverables.
- Integration with Chemical and Analytical Expertise: Because our company also has strong chemistry knowledge and experience (e.g., chemical synthesis, medicinal chemistry, reaction development), the Bio‑Transformation Platform integrates enzymatic methods with broader chemical understanding — enabling hybrid chemical/biocatalytic strategies when needed.
- Mature Workflow: A mature, streamlined workflow that has been validated over many projects, with a track record in selective hydrolysis, asymmetric reductions, chiral amine synthesis, asymmetric double-bond reductions, etc.
Whether you are just evaluating feasibility or preparing for scale-up, our platform offers a comprehensive, efficient, and scalable solution to meet your needs. We welcome potential partners to discuss their project requirements and explore how our Bio‑Transformation Platform can accelerate and de-risk their drug development journey.